Abstract The synthesis of several hydroxylated steroids via conjugate addition of Fleming's silyl-cuprate reagent (PhMe 2 Si) 2 CuLi, a masked hydroxyl group, to the appropriate enone was studied. By this means 7∝-hydroxytestosterone (7) was obtained in good yield from 17β-hydroxyandrosta-4, 6-dien-3-one (1a), though similar reactions of 17β-hydroxyandrosta- 1, 4-dien-3-one (8) gave a low yield of 1∝-hydroxytestosterone (13) chiefly through the ...
![(3S,10R,13S,14S,16R)-16-bromo-10,13-dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-1,3-dioxolane]-3-ol Structure](https://image.chemsrc.com/caspic/165/17921-61-8.png)
![(3S,10R,13S,14S)-10,13-DIMETHYL-1,2,3,4,7,8,9,10,11,12,13,14-DODECAHYDROSPIRO[CYCLOPENTA[A]PHENANTHRENE-17,2'-[1,3]DIOXOLAN]-3-OL Structure](https://image.chemsrc.com/caspic/127/17921-62-9.png)
