The Journal of antibiotics

Synthesis and antibacterial activity of new 2-substituted penems. I.

T Nishi, K Higashi, M Takemura, M Sato

Index: Nishi; Higashi; Takemura; Sato Journal of Antibiotics, 1993 , vol. 46, # 11 p. 1740 - 1751

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Citation Number: 5

Abstract

A new type of penem derivative (3-6) having a cyclic amidine moiety or a quaternary heterocycle moiety at the C-2 position was prepared. The susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. Some of these compounds (5, 6) showed a broad spectrum of antibacterial activity, including activity against Pseudomonas aeruginosa,