Oxidative Radical Arylation of Anilines with Arylhydrazines and Dioxygen from Air

J Hofmann, H Jasch, MR Heinrich

Index: Hofmann, Josefa; Jasch, Hannelore; Heinrich, Markus R. Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2314 - 2320

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Citation Number: 41

Abstract

Substituted 2-aminobiphenyls have been prepared from arylhydrazine hydrochlorides and anilines in biphasic radical arylation reactions with dioxygen from air as a most simple and readily available oxidant. Under optimized conditions, the free amino functionality of the aniline leads to high ortho: meta regioselectivities, now even for anilines bearing a donor substituent in the para position. Finally, the mild and metal-free new access to ...