Synthesis of the silver (i) complex of CH 2 [CH (pz 4Et) 2] 2 containing the unprecedented [Ag (NO 3) 4] 3− anion: A general method for the preparation of 4-(alkyl) …

DL Reger, JR Gardinier, TC Grattan, MR Smith…

Index: Reger, Daniel L.; Gardinier, James R.; Grattan, T. Christian; Smith, Monica R.; Smith, Mark D. New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1670 - 1677

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Citation Number: 36

Abstract

A general two-step method for the syntheses of 4-(alkyl) pyrazoles has been developed. The first step involves the reaction between organyl diethylacetals and the Vilsmeier reagent to give a mixture of ethoxy-and dimethylamino-acroleins. This mixture reacts directly with hydrazine monohydrogenchloride to yield the desired (4-substituted) pyrazoles. The 4- (phenyl) pyrazole derivative exhibited a markedly lower solubility in common organic ...