Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1

B Vaitilingam, A Nayyar, PB Palde, V Monga…

Index: Vaitilingam, Balasubramanian; Nayyar, Amit; Palde, Prakash B.; Monga, Vikramdeep; Jain, Rahul; Kaur, Sukhraj; Singh, Prati Pal Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4179 - 4188

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Citation Number: 45

Abstract

Structural optimization of recently discovered new chemical entity, 2, 8-dicyclopentyl-4- methylquinoline (DCMQ; MIC= 6.25 μg/mL, M. tuberculosis H37Rv) resulted in the synthesis of four new series of ring-substituted quinolinecarboxylic acids/esters constituting 45 analogues. All new derivatives were evaluated for in vitro antimycobacterial activities against M. tuberculosis H37Rv. Certain ring-substituted-2-quinolinecarboxylic acid ester ...