Evidence for a competing condensation reaction in the alloxan synthesis of flavins: synthesis and crystal and molecular structures of 7-chloro-8-methylalloxazine and …

V Kumar, KA Woode, RF Bryan…

Index: Kumar; Woode; Bryan; Averill Journal of the American Chemical Society, 1986 , vol. 108, # 3 p. 490 - 496

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Citation Number: 9

Abstract

Abstract: The reaction of 2-amino-5-chloro-N, 4-dimethylaniline with alloxan monohydrate in boric acid-acetic acid mixtures has been shown to produce 7-chloro-8-methylalloxazine (111) in addition to the expected 8-chlorolumiflavin (I). The position of, heteroatom substitution in I11 and I has been verified by optical and'H NMR studies and by single-crystal X-ray diffraction structure determinations of 111-DMF and of a derivative of I, 8 4 (2- ...