A novel approach to the synthesis of retinoids and arotinoids (including heterocyclic analogs) is described which is based on the thallium-accelerated palladium-catalyzed cross- coupling of boronic acids with a variety of electrophiles (the Suzuki reaction). The recent characterization of the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), 1 which are members of the steroid/retinoid hormone receptor superfamily of ligand- ...
