Recognition of all four base pairs of double-helical DNA by triple-helix formation: design of nonnatural deoxyribonucleosides for pyrimidine. cntdot. purine base pair …

…, LL Kiessling, PA Beal, P Gillespie…

Index: Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B. Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982

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Citation Number: 104

Abstract

Abstract: The sequence-specific recognition of double-helical DNA by oligonucleotide- directed triple-helix formation is limited mostly to purine tracts. Design leads that could expand the recognition code to all four Watsonxrick base pairs would provide one step toward a general solution targeting single sites in megabase size DNA. The nonnatural deoxyribonucleoside 1-(2-deoxy-8-~-ribofuranosyl)-4-(3-benzamidophenyl) imidazole (D3 ...