Many compounds of this series of w-[5-(u-arylalkyl)-2-thienyl]-and w-[4-(w-arylalkyl) phenyl] alkanoic acids were found to be potent in vitro inhibitors of the LTB, production by porcine leukocytes with IC,, ranging from 1 to 10 WM. The side-chain lengths were critical for an optimal activity. Substitutions on the terminal aromatic ring, in the benzene series, by lipophilic and electron-donating substituents substantially enhanced the LTA, hydrolase ...
![4-[2]thienyl-butyric acid ethyl ester Structure](https://image.chemsrc.com/caspic/213/91950-17-3.png)
![2-[4-[5-(3-phenylpropyl)thiophen-2-yl]butoxy]acetic acid Structure](https://image.chemsrc.com/caspic/417/142259-95-8.png)
