Il Farmaco

Synthesis and choleretic activity of 3-[2-(3-R', 4-R'', 5-R'''-benzyl)-5-R-benzimidazol-1-yl]-butanoic acids

…, G Paglietti, F Sparatore, M Satta, P Manca, AT Peana

Index: Grella; Paglietti; Sparatore; Satta; Manca; Peana Farmaco, 1992 , vol. 47, # 1 p. 21 - 35

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Citation Number: 7

Abstract

On the ground of the evidentiated choleretic activity of 3-[2-benzylbenzimidazol-1-yl] butanoic acid, 28 new acids were prepared in order to evaluate the influence of suitable substitutions in either C5 of heteroring or C3', C4', C5'of benzyl group in position 2 on the choleretic activity. Pharmacological results after iv administration of 0.5 mmol/Kg in rats confirmed a general high choleretic activity that in eleven cases showed during the first 4 ...