Discovery and Evaluation of 7-Alkyl-1, 5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein …

LH Pettus, RP Wurz, S Xu, B Herberich…

Index: Journal of Medicinal Chemistry, , vol. 53, # 7 p. 2973 - 2985

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Citation Number: 28

Abstract

... Journal of Medicinal Chemistry. ... The proven ability of p38α MAP kinase to regulate both the production and the activity of these cytokines has prompted many pharmaceutical groups to pursue orally active inhibitors of p38α for the potential treatment of various inflammatory ...