This paper describes the s>-ri~ hesis and aiit imicrokiial eva1ii: il ioii of 5-i5-riit rofiir~ lideiie) i~ li~~ daiiiiie~. arid>-(. j-iiitrofuryliderie) thiazolidirie-L', 4-dioiies siibstit, uted iii the 3 posit ion with the object of modifyiiig the soliibilit y, physical properties, atid niicrobial reduct ion pat tent iii the sei, ie-. Srinie viiiylogs of t hese conip (ii~ iids were also prepared. The antibacterial, aritiprotuzoal, tirid ariiifiiiigal iLctivi1 ieq of t hese c* ompowids were conip: ...