Abstract A series of oximinopropanolamines derived from dicyclopropyl ketone, in which the amine substituents were alkyl, cycloalkyl, aryl and aralkyl groups, has been synthesized. The β-adrenergic blocking properties were determined on anaesthetized rats. Two N-aralkyl derivatives were found to be as potent as propranolol and compound 11 was twice as active as propranolol. Some structure-activity relationships are discussed.
