Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions

TM Bertolini, J Giorgione, DF Harvey…

Index: Bertolini, Thomas M.; Giorgione, Jennifer; Harvey, Daniel F.; Newton, Alexandra C. Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5028 - 5036

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Citation Number: 25

Abstract

Several novel phorbol esters were prepared with polar functional groups terminating their C12 and/or C13 acyl chains. Designed to be inhibitory protein kinase C (PKC) ligands, these phorbol analogues contain various polar functional groups (amide, ester, carboxylic acid, or quaternary ammonium salt) to prevent membrane insertion of the PKC-phorbol ester complex. All phorbol derivatives were synthesized with use of diterpene starting materials ...