Resolution of (±)-1-Aryl-2-propynylamines via Acyltransfer Catalyzed by Candida antarctica Lipase

…, M Botta, F Corelli, MP Schneider…

Index: Messina; Botta; Corelli; Schneider; Fazio Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3767 - 3769

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Citation Number: 55

Abstract

Chiral 1-ethynylbenzylamines (1) are important building blocks for the stereoselective synthesis of numerous biologically active compounds, such as conformationally restricted peptide isosteres, 1 oxotremorine analogues, 2 and benzo [b] furan compounds of general structure 2 (eq 1), which have been shown to display antifungal and aromatase inhibiting activities. 3