On the quantitative relations between structure and antiaggregation activity of ω-aryl-ω-oxoalkanoic acids

…, B Brunová, J Grimová, V Rejholec…

Index: Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625

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Citation Number: 4

Abstract

Abstract A series of ω-aryl-ω-oxoalkanoic acids, I-IV, has been prepared and investigated for dissociation constants in 80% methylcellosolve, retention characteristics in thin-layer partition chromatography and partition coefficients P in the system octanol-water. Also evaluated were their anti-inflammatory efficacy and inhibitory effect on the platelet aggregation induced by collagen. Analysing the relations between structure and ...

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