Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidine nucleosides related to toyocamycin and sangivamycin

…, LL Wotring, JC Drach, LB Townsend

Index: Gupta, Pranab K.; Nassiri, M. Reza; Coleman, Lisa A.; Wotring, Linda L.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1420 - 1425

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Citation Number: 34

Abstract

N, isomer. Debromination of this mixture gave the corresponding 4-amino-5-cyano-7-[(2- acetoxyethoxy)-methyl] pyrrolo [2, 3-d] pyrimidine (4) and 4-amino-5-cyano-1-[(2- acetoxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidine (5). Deacetylation of 4 and 5 furnished 4- amino-5-cyano-7-[(2-hydroxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidine(6) and the corresponding N1 isomer (7), respectively. The sites of attachment for the acyclic moiety ...