Chemical and pharmaceutical bulletin

1, 5-Dimethyl-6H-pyridazino [4, 5-b] carbazole, a 3-Aza Bioisoster of the Antitumor Alkaloid Olivacine.

N Haider, E Sotelo

Index: Haider, Norbert; Sotelo, Eddy Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 11 p. 1479 - 1483

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Citation Number: 40

Abstract

A series of b-fused carbazoles structurally related to pyrido [4, 3-b] carbazole-type alkaloids was prepared, utilizing the Diels–Alder reaction of 1-methylpyrano [3, 4-b] indol-3 (9H)-one with electron-deficient acetylenic dienophiles as the key step. The title compound (14) thus obtained in only four steps represents a new 3-aza analog of the antitumor natural product, olivacine.