Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents

…, FL Boyd, CJ Sexton, DW Selleseth, KL Creech…

Index: Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Samano, Vicente A.; Ray, John A.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Creech, Katrina L.; Moniri, Kelly R. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2397 - 2411

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Citation Number: 47

Abstract

A novel series of potent pyrazolo [1, 5-a] pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage intermediates. Detailed examination of the amine substituents at the C2′ position of the pyrimidine and C7 position of the core pyrazolopyridine is described. The antiviral data suggests that non- ...