The Journal of organic chemistry

Total synthesis of (+)-angelmarin

J Magolan, MJ Coster

Index: Magolan, Jakob; Coster, Mark J. Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5083 - 5086

Full Text: HTML

Citation Number: 29

Abstract

An anti-austerity therapeutic strategy, targeting this metabolic adaptation of cancer cells, was proposed in 2000 by Esumi and co-workers.(2a) Through the development of an assay method for antiausterity activity,(4) several natural products have been identified with preferential cytotoxicity to PANC-1 cells in nutrient-deprived medium while showing no activity in nutrient-sufficient medium.(5) Two of these compounds, kigamicin D(5a) and arctigenin,(5c) were further ...