Abstract: A series of N-14 sidechain substituted analogues of styelsamine (pyrido [4, 3, 2- mn] acridine) and cystodytin (pyrido [4, 3, 2-mn] acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a panel of human tumor cell lines. Overall it was found that styelsamine analogues were stronger DNA binders, with the natural products styelsamines B and D having particularly ...
