Tetrahedron

“Fries like” rearrangement: A novel and efficient method for the synthesis of 6-acyl-2 (3H)-benzoxazolones and 6-acyl-2 (3H)-benzothiazolones

…, P Depovere, D Lesieur, M Isa, B Masereel, J Delarge…

Index: Ucar, Huseyin; Van Derpoorten, Kim; Depovere, Paul; Lesieur, Daniel; Isa, Majed; Masereel, Bernard; Delarge, Jacques; Poupaert, Jacques H. Tetrahedron, 1998 , vol. 54, # 9 p. 1763 - 1772

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Citation Number: 21

Abstract

6-acyl-2 (3H)-benzoxazolone and 6-acyl-2 (3H)-benzothiazolone derivatives have particularly interesting anti-inflammatory, antiepileptic, analgesic and antiviral properties. In this study, we report an original method of acylation on the 6-position of 2 (3H)- benzoxazolone and 2 (3H)-benzothiazolone which consists in a two-step procedure involving migration of the acyl group from the N-position to the 6-position of the ...