Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123

BM Kinsey, AI Kassis, F Fayad, WW Layne…

Index: Kinsey, Berma M.; Kassis, Amin I.; Fayad, Fahed; Layne, Warren W.; Adelstein, S. James Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1757 - 1761

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Citation Number: 42

Abstract

1 compound is greater in certain types of cancer cells than in normal cells (10-20-fold)> and the compound exhibits selective toxicity in certain cancer cells in vitro10-12 and in vivo. 13 It has been postulated that the increased accumulation by tumor cells may be due to the elevated mitochondrial and plasma membrane potentials in these cells. 14