e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Cuprous chloride accelerated Stille reactions. A general and effective coupling system for sterically congested substrates and for enantioselective synthesis
X Han, BM Stoltz, EJ Corey
Index: Han, Xiaojun; Stoltz, Brian M.; Corey Journal of the American Chemical Society, 1999 , vol. 121, # 33 p. 7600 - 7605
A major limitation of Stille coupling reactions arises from steric screening, especially in the vinylstannane component. For example, with 1-substituted vinylstannanes and aryl perfluoroalkanesulfonates or halides negligible or low yields are generally observed, due to very slow reaction rates and competing cine substitution. This problem has been overcome in the present work through the discovery and application of cuprous chloride as an ...
