Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors

…, S Massa, D Rotili, S Simeoni, R Ragno…

Index: Mai, Antonello; Massa, Silvio; Lavu, Siva; Pezzi, Riccardo; Simeoni, Silvia; Ragno, Rino; Mariotti, Francesca R.; Chiani, Francesco; Camilloni, Giorgio; Sinclair, David A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7789 - 7795

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Citation Number: 47

Abstract

A novel series of compounds containing a uracil moiety as the connection unit between a phenyl/phenylalkyl portion and a N-hydroxy-polymethylenealkanamide or- methylenecinnamylamide group (uracil-based hydroxamic acids, UBHAs) was tested against maize histone deacetylases (HDACs) and mouse HDAC1. Compounds with a phenyl/benzyl ring at the uracil-C6 position and bearing 4-5 carbon units as well as a m-or ...