On the other hand, many organometallic reactions have been demonstrated to proceed in aqueous media in recent years. 7 This is possible when the organometallic reagent has low reactivity towards water and is formed in the reaction medium by mixing the metal, halide and electrophilic substrate in a one-pot reaction, commonly known as Barbier-type reaction. ... There is general agreement about the advantages of the use of water as solvent. Water is the cheapest ...
