In the search for improved lipophilic centrally active acetylcholinesterase (AChE) antidotes, a series of a-keto thiohydroximates were prepared and evaluated for their ability to reactivate AChEs inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and soman (GD). The compounds conformed to the general structure 4-RCBH5C-(O) C (NOH) S (CH,), N+ R'R''-X-where R= H, CH,, F, Br, C1, OCH,, CN; R'= CH,, CzH5, iC, H,; R”= H, CH,; X= ...
