Chloromycetin (Chloramphenicol1). Related Compounds Having Alkyl Side Chain Variations

MC Rebstock, GW Moersch, AC Moore…

Index: Rebstock et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3666,3670

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Citation Number: 9

Abstract

During the preparation of compounds related to Chloromycetin,~-(levo)-fhreo-~-n~ trophenyl- 2-dichloroacetamido-1, 3-propanediol, a number were synthesized with variations in the alkyl side chain. In the present series changes were made in carbon atoms (1) and/or (3) which involved either the replacement of hydroxyl with hydrogen or alkyl or the complete omission of these carbon atoms from the structure. Nitration of the acetyl derivatives of ...