Tetrahedron letters

Synthesis of 3, 5-disubstituted 1, 2, 4-oxadiazoles as peptidomimetic building blocks

Ž Jakopin, R Roškar, MS Dolenc

Index: Jakopin, Ziga; Roskar, Robert; Dolenc, Marija Sollner Tetrahedron Letters, 2007 , vol. 48, # 8 p. 1465 - 1468

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Citation Number: 33

Abstract

Twelve new 1, 2, 4-oxadiazole based compounds have been synthesized. Their structures contain a protected amine and a carboxyl or an ester group, and thus serve as potential peptidomimetic building blocks. The synthetic route is simple and mild conditions are used so that the chirality of the starting amino acids is retained.