A series of quinolyl carbanilates wm prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structureactivity relationship study indicated that 8-quinolyl4-methoxycarbanilate (1) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl ...
