Sequence-specific targeting and cleavage of nucleic acids (in DNA or RNA) can be achieved using oligo-2'-deoxyribonucleotides (ODN) or peptide nucleic acids (PNA) covalently attached to a reactive chemical.[1] These conjugates combine the ability to recognize (through the ODN or the PNA) and react (through the chemical) with a selected sequence, which thus can be either redox cleaved or hydrolyzed. However, the great ...
