Indium (III)-catalyzed addition of diethyl acetamidomalonate to terminal alkynes: An efficient approach to β-branched α-amino acids

P Angell, PG Blazecka, M Lovdahl…

Index: Journal of Organic Chemistry, , vol. 72, # 17 p. 6606 - 6609

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Citation Number: 14

Abstract

... Journal of Organic Chemistry. ... a Reaction conditions for 1−7 mmol of substituted malonates 3a,d,f,j−l: (i) Pd(C) or Pt(C)/H 2 50 psi, EtOH or THF, 3−16 h at 20−25 °C; (ii) 6 N aqueous HCl (w/ or w/o p-dioxane), 16−24 h at 90−100 °C. The reaction time was not optimized. ...