Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

X Lang, L Li, Y Chen, Q Sun, Q Wu, F Liu, C Tan…

Index: Lang, Xuliang; Li, Lulu; Chen, Yuzong; Sun, Qinsheng; Wu, Qin; Liu, Feng; Tan, Chunyan; Liu, Hongxia; Gao, Chunmei; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4170 - 4177

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Citation Number: 26

Abstract

Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these ...