The barcoded resins (BCRs) are spectroscopically encoded polymers with unique Raman and infrared vibrational spectra. 1 Each BCR may be used as a carrier for a small molecule or a receptor and used in encoded combinatorial screening or as a high-throughput diagnostic tool, respectively. Because of their unique polymeric matrix composition, the BCRs may be simultaneously identified using hyperspectral 2 and/or time-of-flight secondary ion mass spectrometry 3 ...