New quinoline-based caging groups synthesized for photo-regulation of aptamer activity

…, J Shi, R Cai, XY Chen, ZF Luo, QX Guo

Index: Li, Yi Ming; Shi, Jing; Cai, Rong; Chen, XiaoYun; Luo, Zhao Feng; Guo, Qing Xiang Journal of Photochemistry and Photobiology A: Chemistry, 2010 , vol. 211, # 2-3 p. 129 - 134

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Citation Number: 12

Abstract

A series of quinoline-based photo-removable protecting groups for photo-regulation of thrombin aptamer (HD1) activity were synthesized with improved caging and uncaging efficiency. Among them, 8-bromo-2-diazomethyl-7-hydroxyquinolinyl (BHQ-diazo, 1) chromophore was found to cage the HD1 with highest caging and restoration efficiency. Moreover, on the basis of the RP-HPLC and SPR analysis, BHQ was demonstrated to ...