We have developed an efficient and robust route to synthesize 4, 5, 7-trisubstituted pyrrolo [3, 2-d] pyrimidines as potent kinase inhibitors. This solution-phase synthesis features a SNAr substitution reaction, cross-coupling reaction, one-pot reduction/reductive amination and N-alkylation reaction. These reactions occur rapidly with high yields and have broad substrate scopes. A variety of groups can be selectively introduced into the N5 and C7 ...
![3,5-DIHYDRO-7-NITRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Structure](https://image.chemsrc.com/caspic/475/93587-26-9.png)
![4-Chloro-7-nitro-5H-pyrrolo[3,2-d]pyrimidine Structure](https://image.chemsrc.com/caspic/051/1260676-83-2.png)