Abstract A new, straightforward and high-yielding methodology for the asymmetric synthesis of 2-(1, 3-dioxolan-4-yl) piperidines is described. This approach involves a highly stereoselective addition of vinylmagnesium bromide to N-(3-butenyl) imines derived from d- glyceraldehyde diphenyl ketal and a ring-closing metathesis reaction as key steps. This procedure was used for the first asymmetric synthesis of (S)-2-[(S)-2, 2-diphenyl-1, 3- ...
![benzyl (2S)-2-[(4S)-2,2-diphenyl-1,3-dioxolan-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate Structure](https://image.chemsrc.com/caspic/264/1247664-50-1.png)
![(2S)-2-[(4S)-2,2-Diphenyl-1,3-dioxolan-4-yl]piperidine Structure](https://image.chemsrc.com/caspic/224/4741-41-7.png)