1-Hydroxy-1, 4-dihydroquinoxaline-2, 3-diones: Novel antagonists at NMDA receptor glycine sites

…, V Ilyin, JE Hawkinson, RM Woodward, E Weber…

Index: Zheng, Hua; Espitia, Stephen A.; Ilyin, Victor; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F. W. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 4 p. 439 - 440

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Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 1-hydroxy-1,4-dihydroquinoxaline-2,3-diones was synthesized and assayed for NMDA receptor glycine site antagonism. Except for 4a, these were found to be 3–80 times weaker antagonists than the analogous 1,4-dihydroquinoxaline-2,3-diones. ... A series of 1-hydroxy-1,4- ...