Bioorganic & medicinal chemistry letters

Organic phenyl arsonic acid compounds with potent antileukemic activity

XP Liu, RK Narla, FM Uckun

Index: Liu, Xing-Ping; Narla, Rama Krishna; Uckun, Fatih M. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 581 - 583

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Citation Number: 24

Abstract

A series of 12 organic arsonic acid compounds has been synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. The lead compounds 2-trichloromethyl-4-[4′-(4 ″-phenylazo) phenylarsonic acid] aminoquinazoline (compound 19, PHI-P518; IC50= 1.1±0.5 μM against NALM-6 and 2.0±0.8 μM against MOLT-3) and 2-methylthio-4-(2′-phenylarsonic acid) ...

~84%

Quinazolines as cyclin dependent kinase inhibitors

[Sielecki, Thais M.; Johnson, Tricia L.; Liu, Jie; Muckelbauer, Jodi K.; Grafstrom, Robert H.; Cox, Sarah; Boylan, John; Burton, Catherine R.; Chen, Haiying; Smallwood, Angela; Chang, Chong-Hwan; Boisclair, Michael; Benfield, Pamela A.; Trainor, George L.; Seitz, Steven P. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1157 - 1160]