Abstract In a continued structural modification study of the antimalarial compounds 3- piperonylsydnone and 2, 4-diamino-5-piperonylpyrimidine, the related piperonyl derivatives of ψ-1, 2, 3; 4-oxatriazole, ψ-1, 3, 5-oxadiazole, pyrazole, tetrazole, 1, 2, 4-triazine, pyrrolidine, amino-and sulfamoyl-1, 2, 4-triazole, as well as some sydnones and diaminopyrimidines with side chains other than the piperonyl group have been ...