Synthesis and diuretic activity of 3, 3-spiro-substituted hydrothiazides

EJ Cragoe, OW Woltersdorf, JE Baer…

Index: Cragoe,E.J. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 896 - 912

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Citation Number: 11

Abstract

Forty-one 3, 3-spiro-sul, stituted 1i) drothiazitlPs\ wre synthesized by thc co~ i-densation of substituted 4-amino-], 3-1) enaeriedisulfonaniides with cyclic ketones or the corresponding ethylene ketals. Five different synthetic procedures were employed and a comparison of these: md other methods n-as made using the reaction of 4-amino-6-chloro-1, 3-I~ enzeri~ disulfo1i~ i~ ii~~~~ with cyclohexanone as a prototype.