Sansalvamide A, a cyclic depsipeptide isolated from a marine fungus of the genus Fusarium, is composed of four hydrophobic amino acids (Phe, two Leu, Val) and one hydroxy acid ((S)- 2-hydroxy-4-methylpentanoic acid; O-Leu) with five stereogenic centers all having S- stereochemistry. We have recently synthesized the corresponding cyclic peptide (Gu, W.; Liu, S.; Silverman, RB Organic Lett. 2002, 4, 4171-4174) and found that it too has ...
