As part of our continuing interest in promising new scaffolds as inhibitors of kinases, we focused our research on 5-substituted 2,4-bis-aminoaryl pyridines (BAPyds). Very few synthetic methods have been reported in the literature, [ 1 1. Tasler , S. ; Mueller , O. ; Wieber , T. ; Herz , T. ; Krauss , R. ; Totzke , F. ; Kubbutat , MHG ; Schaechtele , C. N-Substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping . Bioorg. Med. Chem. Lett. ...
