A Scaleable Synthesis of Dutasteride: A Selective 5α-Reductase Inhibitor†

…, K Srinivas, V Himabindu, GM Reddy

Index: Satyanarayana, Komati; Srinivas, Katkam; Himabindu, Vurimidi; Reddy, Ghanta Mahesh Organic Process Research and Development, 2007 , vol. 11, # 5 p. 842 - 845

Full Text: HTML

Citation Number: 19

Abstract

Dutasteride (1) is a selective inhibitor of the type 1 and type 2 isoforms of steroid 5α-reductase (5 AR),(1) an intracellular enzyme that converts testosterone to 5α-dihydrotestosterone (DHT). Dutasteride (1) is currently available in the market as a drug for benign prostatic hyperplasia(2) under the brand name of AVODART and is used for the treatment of prostate diseases such as prostate cancer, acne, male pattern baldness, hirsutism, and prostate gland ...