The Journal of organic chemistry

Au (III)/TPPMS-Catalyzed Benzylation of Indoles with Benzylic Alcohols in Water

H Hikawa, H Suzuki, I Azumaya

Index: Hikawa, Hidemasa; Suzuki, Hideharu; Yokoyama, Yuusaku; Azumaya, Isao Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6714 - 6720

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Citation Number: 23

Abstract

A novel and efficient method for the Au (III)/TPPMS-catalyzed direct substitution reaction of benzhydryl and benzylic alcohols with indoles in water is developed. Au (III)/TPPMS is an effective catalyst for the benzylation of the strong π nucleophile 1-methylindole, while common Brønsted or Lewis acids are ineffective.