Synthesis and biological evaluation of thiazolo-triazole derivatives

…, S Mazzone, AM Panico, G Mazzone, G Pennisi…

Index: Pignatello; Mazzone; Panico; Pennisi; Castana; Matera; Blandino European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 929 - 938

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Citation Number: 58

Abstract

Abstract Two series of isomeric thiazolo [3, 2-b][1, 2, 4] triazole and thiazolo [2, 3-c][1, 2, 4] triazole derivatives were prepared following multiple synthetic pathways. The obtained compounds were submitted to preliminar pharmacological assays to evaluate their anti- inflammatory, analgesic and antipyretic activity. Suggestions about structure-activity relationships between the two classes of isomers were delineated. Moreover, some of the ...