Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens

…, GJ Cleek, LA Dolak, SA Garmon, J Morris…

Index: Barbachyn, Michael R.; Cleek, Gary J.; Dolak, Lester A.; Garmon, Stuart A.; Morris, Joel; Seest, Eric P.; Thomas, Richard C.; Toops, Dana S.; Watt, William; Wishka, Donn G.; Ford, Charles W.; Zurenko, Gary E.; Hamel, Judith C.; Schaadt, Ronda D.; Stapert, Douglas; Yagi, Betty H.; Adams, Wade J.; Friis, Janice M.; Slatter, J. Gregory; Sams, James P.; Oien, Nancee L.; Zaya, Matthew J.; Wienkers, Larry C.; Wynalda, Michael A. Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 284 - 302

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Citation Number: 69

Abstract

A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as important new therapeutic agents for the treatment of infections caused by Gram-positive bacteria. Because of their significance, extensive synthetic investigations into the structure- activity relationships of the oxazolidinones have been conducted at Pharmacia. One facet ...