The enantiomers of 2-and 3-hydroxymethyl substituted 2, 3-dihydro [1, 4] dioxino [2, 3-b] pyridine 1 and 2, important chiral building blocks for the preparation of several biologically active compounds, were synthesized.(S)-and (R)-1 were obtained from either one or both the enantiomers of benzylglycerol, while (S)-and (R)-2 were obtained from (R)-and (S)- isopropylideneglycerol, respectively. The novel efficient synthetic strategies, which do not ...
