2, 4-thiazolidinediones as potent and selective human β 3 agonists

B Hu, J Ellingboe, I Gunawan, S Han, E Largis…

Index: Hu, Baihua; Ellingboe, John; Gunawan, Iwan; Han, Stella; Largis, Elwood; Li, Zenan; Malamas, Michael; Mulvey, Ruth; Oliphant, Alexander; Sum, Fuk-Wah; Tillett, Jeff; Wong, Victoria Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 757 - 760

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Citation Number: 47

Abstract

Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC 50 =0.01 μM, IA=1.19) and selective (more than 110-fold over β 1 and β 2 agonist activity) β 3 agonist. This compound has also been proven to be active and selective in an in vivo mode. ... 2,4-Thiazolidinedione 22c is a potent and selective human β 3 agonist. ... The β 3 -adrenergic receptor (β 3 -AR) has been shown to mediate various pharmacological and physiological effects such as ...