Synthesis and Properties of 6, 7, 8-Substituted 2-(4-Oxo-3, 4-dihydro-2-quinazolinyl) acetonitriles

YM Volovenko, OV Khilya, TA Volovnenko…

Index: Volovenko; Khilya; Volovnenko; Shokol Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 3 p. 314 - 323

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Citation Number: 3

Abstract

Abstract 2-(4-Oxo-3, 4-dihydro-2-quinazolinyl) acetonitriles have been obtained by the interaction of α-cyanoethylthioiminoacetate with substituted anthranilic acids. Prototropy became apparent in the series of synthesized compounds. Reactions of the 2-(4-oxo-3, 4- dihydro-2-quinazolinyl) acetonitriles have been carried out with (hetero) aromatic aldehydes leading to the formation of 3-aryl-2-(4-oxo-3, 4-dihydro-2-quinazolinyl) acrylonitriles.